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Date of publication:2020/6/8 15:03:49
Boronic Acids

A boronic acid is a compound related to boric acid in which one of the three hydroxyl groups is replaced by an alkyl or aryl group (R-B(OH)2).  As compounds containing carbon-boron bonds, such members thus belong to a larger class of organoborane. Generally, boronic acid acts as a Lewis acid (a chemical substance that contains an empty orbital that can accept electron pairs from a Lewis base to form a Lewis adduct). They are unique in that they can form reversible covalent complexes with sugars, amino acids, hydroxamic acids, etc. They are sometimes used in molecular recognition to bind sugar, for fluorescence detection or selective transport of sugar across the membrane.

Boronic-acid

Boronic acid is widely used as a chemical component and intermediate in organic chemistry, mainly used in Suzuki coupling. A key concept in its chemistry is transmetallation of its organic residue to a transition metal.

The boronic acid functional group is considered to have low inherent toxicity. This is one of the reasons for the popularization of Suzuki coupling agents in drug development and synthesis.

In supramolecular chemistry, boronic acid is used for the recognition of molecules binding to saccharides and for the fluorescent detection, or selective transport, of saccharides across membranes.

Boronic Esters

Boronic esters (RB(OR)2), also referred to as boronate esters, are formed between boronic acid and an alcohol. They are stable compounds, although the -C-B- bond of boronic ester is slightly longer than C-C single bonds. Boronic esters are very easy to purify and characterize. They have enhanced reactivity, higher compatibility with many reagents, better solubility in organic solvents, and are also used as good protecting groups to eliminate unwanted side reactions. With their excellent ability to construct C-C bonds via metal-catalyzed cross-coupling, boronic esters have received much attention for use in organic synthesis. The boronic esters are widely used for carrying out cross-coupling reactions. Boronic acid esters are used in the Suzuki-Miyaura coupling reaction for synthesizing unsymmetrical biaryls, which has wide use in pharmaceuticals and agrochemical industries.
Boronate-ester
 
Huateng Pharma is known worldwide for a variety of chemical compounds used in research and development. Recognized for purity and quality, our products and brands are backed by technical and sales teams dedicated to providing you the best service possible. Below, you will find some featured boronic acids, esters of our company. Many more products, including high purity pharmaceutical intermediates, PEG derivatives, and fine chemicals are available online at https://en.huatengsci.com/.

 

1201905-61-4

(E)-1-Ethoxyethene-2-boronic acid pinacol ester
CAS NO.:1201905-61-4

279262-23-6

[4-(MORPHOLINOMETHYL)PHENYL]BORONIC ACID
CAS NO. 279262-23-6

917757-15-4

3-METHOXY-4-METHYLBENZENEBORONIC ACID
CAS NO.:917757-15-4

313546-18-8

2-METHYL-4-CYANOPHENYLBORONIC ACID
CAS NO. 313546-18-8

1282518-60-8

1-Isopropyl-1H-pyrazole-5-boronic acid,pinacol ester
CAS NO.:1282518-60-8

847818-70-6

1-Ethyl-1H-pyrazole-4-boronic acid,pinacol ester
CAS NO.:847818-70-6

879487-10-2

1-Isopropylpyrazole-4-boronic acid,pinacol ester
CAS NO. 879487-10-2

180516-87-4

4-CARBOXYLPHENYLBORONIC ACID PINACOL ESTER
CAS NO. 180516-87-4

847818-55-7

1-Methyl-1H-pyrazole-4-boronic acid
CAS NO. 847818-55-7

1282518-60-8

1-Isopropyl-1H-pyrazole-5-boronic acid,pinacol ester
CAS NO.1282518-60-8

1007110-53-3

1-Ethylpyrazole-5-boronic acid,pinacol ester
CAS NO. 1007110-53-3

847818-70-6

1-Ethyl-1H-pyrazole-4-boronic acid,pinacol ester
CAS NO. 847818-70-6

164014-95-3

1,4-BENZODIOXAN-6-BORONIC ACID
CAS NO. 164014-95-3

849061-99-0

(E)-2-Cyclopropylvinylboronic acid pinacol ester
CAS NO. 849061-99-0

935685-88-4

3-Cyano-5-fluorobenzeneboronic acid pinacol ester
CAS NO. 935685-88-4