Baloxavir marboxil, marketed as Xofluza, is a first-in-class, one-dose oral agent first approved by the FDA in 2018 for the treatment of acute, uncomplicated influenza in individuals 12 years and older, who have been symptomatic for less than 24 hours.
China is the country with the largest number of incidences and deaths from gastric cancer in the world. According to the latest global cancer data released by the World Health Organization International Agency for Research on Cancer (WHO IARC) in 2020, there are 1.089 million new cases of gastric cancer worldwide and 0.768 million deaths in 2020. There are 478,000 new cases of gastric cancer (43.9%) and 373,000 deaths from gastric cancer (48.5%) in China.
On March 1, 2021, the team of Xiaoping Yang from Hunan Normal University published an online research paper titled: Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis in the Journal of Signal Transduction and Targeted Therapy.
Piroctone olamine (also known as piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. It is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione. What is piroctone olamine? What're the benefits and side effects of it?
On the 100th anniversary of the discovery of insulin, on January 27, Nature published a milestone study in the field of diabetes. Researchers from the Helmholtz Zentrum Muenchen of the Technical University of Munich, Germany, and the German Diabetes Research Center discovered a new type of drugable insulin inhibitory receptor (named inceptor by the author) that blocks the function of this receptor and results in increased sensitivity of the insulin signaling pathway in pancreatic β-cells.
In a new study, they investigated one of the lncRNA MaTAR25 (Mammary Tumor Associated RNA 25). The results showed that knocking out MaTAR25 would reduce the proliferation, migration and invasion of cancer cells. Moreover, the increased expression of the human ortholog of MaTAR25, LINC01271, is associated with poor prognosis and poor metastasis.