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Intermediates

2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene

2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
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Synonyms
Canagliflozin INT4;Canagliflozin intermediate2
Catalog ID
94665
CAS NO.
1030825-20-7
Purity
MDL Number
MFCD21496340
EINECS
Molecular formula
C18H14BrFS
Molecular weight
361.27
  • Appearance：
    Off-white solid
Application:  CAS no. 1030825-20-7 is an intermediate of Canagliflozin, a selective SGLT-2 Inhibitor used to treat type 2 diabetes. 

References:
1. Liang Y, Arakawa K, Ueta K, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555. doi:10.1371/journal.pone.0030555
2. Nomura S, Sakamaki S, Hongu M, et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem. 2010;53(17):6355-6360. doi:10.1021/jm100332n

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