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Intermediates

2-Chloro-5-aminophenol

2-Chloro-5-aminophenol
User Evaluation Collection Products
Catalog ID
810809
CAS NO.
6358-06-1
Purity
95%
MDL Number
MFCD01707858
EINECS
Molecular formula
C6H6ClNO
Molecular weight
143.5709
  • Appearance：
    Almost white powder
  • Meltingpoint：
    159~160℃
Application: 2-Chloro-5-aminophenol (CAS NO.6358-06-1) is used in the synthesis of antimalarial quinolones. Also used in the synthesis of potent anti-HIV agents based upon pyrimidinylphenylamine.

References:
1. Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones. J Med Chem. 2011;54(24):8321-8327. doi:10.1021/jm200718m
2. Jorgensen WL, Bollini M, Thakur VV, Domaoal RA, Spasov KA, Anderson KS. Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase. J Am Chem Soc. 2011;133(39):15686-15696. doi:10.1021/ja2058583

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