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Ibrutinib

Ibrutinib
User Evaluation Collection Products
Catalog ID
92186
CAS NO.
936563-96-1
Purity
99%
MDL Number
MFCD20261150
EINECS
Molecular formula
C25H24N6O2
Molecular weight
440.5
  • Density:
    1.34g/cm3

Please be kindly noted that our product can only be used for research to organizations or companies and we don't cooperate with personal buyers.

Application: Ibrutinib is a small-molecule inhibitor of BTK for the treatment of hematologic tumors such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and Warf's macroglobulinemia (WM). 

Mechanism: 
Ibrutinib is an BTK inhibitor that forms a covalent bond with a cysteine residue in the active site of BTK (Cys481), leading to its inhibition. The inhibition of BTK plays a role in the B-cell receptor signaling and thus, the presence of ibrutinib prevents the phosphorylation of downstream substrates such as PLC-γ. 

Huateng Pharma. can provide Ibrutinib (CAS NO.936563-96-1 )from milligram to kilogram or even tons scale. Contact us at sales@huatengusa.com for more details. 

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