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Application: Ibrutinib is a small-molecule inhibitor of BTK for the treatment of hematologic tumors such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and Warf's macroglobulinemia (WM).
Mechanism:
Ibrutinib is an BTK inhibitor that forms a covalent bond with a cysteine residue in the active site of BTK (Cys481), leading to its inhibition. The inhibition of BTK plays a role in the B-cell receptor signaling and thus, the presence of ibrutinib prevents the phosphorylation of downstream substrates such as PLC-γ.
Huateng Pharma. can provide Ibrutinib (CAS NO.936563-96-1 )from milligram to kilogram or even tons scale. Contact us at sales@huatengusa.com for more details.
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